A delinquent slut volunteers for a study, and ends up at the tender mercies of the cruel, enema obsessed Nurse Claire. The naive Madison is put in excruciatingly tight bondage and detained with relentless, humiliating enemas.

Taylor Brady Wakes up to find herself fully suspended from the ceiling hung upside down in a strange place. She begins to struggle and cry out. From the shadows nurse Gina emerges and explains that she is at the bondage clinic and she can expect to be constantly bound and receive enemas.